Subcutaneous tissue reaction to modified Portland cement (CPM)

João Eduardo Gomes-Filho, Max Douglas Faria, Simone Watanabe, Carolina Simonetti Lodi, Luciano Tavares Angelo Cintra, Elói Dezan Júnior, Pedro Felício Estrada Bernabé

Introduction: The aim of this study was to evaluate the rat subcutaneous tissue response to implanted polyethylene tubes filled with Modified Portland Cement (CPM®) (Egeo S.R.L., Buenos Aires, Argentina) compared with Angelus MTA® (Angelus, Londrina, Brazil). Methods: These materials were placed in polyethylene tubes and implanted into dorsal connective tissue of Wistar rats for 7, 15, 30, 60, and 90 days. The specimens were prepared and stained with hematoxylin and eosin or Von Kossa or not stained for polarized light. Qualitative and quantitative evaluations of the reaction were performed. Results: Both materials caused moderate reactions at 7 days that decreased with time. Angelus MTA® caused mild reactions at 15 days that decreased with time. The response was similar to the control on 30, 60 and 90 days with CPM® and Angelus MTA®. Mineralization and birefringent to the polarized light granulations were observed with both materials. Conclusions: It was possible to conclude that CPM® and Angelus MTA® were biocompatible in the rat model, and that they stimulated mineralization.

Keywords: Biocompatibility. Connective tissue. Mineral trioxide aggregate.

How to cite: Gomes Filho JE, Faria MD, Watanabe S, Lodi CS, Cintra LTA, Dezan Junior E, Bernabé PFE. Subcutaneous tissue reaction to modified Portland cement (CPM). Dental Press Endod. 2012 Apr-June;2(2):47-52.

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