Do root canal sealers lead to cancer? How can we find out?

Nicole Gonçalves Lima, Mariana Trevizan, Fabrício Kitazono De Carvalho, Paulo Nelson-Filho e Alberto Consolaro

Root canal sealers can be made with calcium hydroxide, zinc oxide and eugenol, glass ionomer, resin associated with methacrylate or silicone. They should be subjected to investigation on their potential for genotoxic and mutagenic effects before being launched into the specialized market, since such properties are part of the biocompatibility concept. In the present study, test modalities and the concepts of genotoxicity, mutagenicity and carcinogenesis are highlighted.

Keywords: Root canal sealing material. Micronucleus test. Comet assay. Biocompatible material.

How to cite: Lima NG, Trevizan M, Carvalho FK, Nelson-Filho P, Consolaro A. Can root canal sealers induce cancer? How can we investigate that? Dental Press Endod. 2016 Jan-Apr;6(1):11-4. DOI: http://dx.doi.org/10.14436/2358-2545.6.1.011-014.end

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