Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: A systematic review

Eduardo MACHADO, Patricia MACHADO, Paulo Afonso CUNALI

Introduction: Degenerative changes in Temporomandibular Joint (TMJ) have increased in prevalence and severity over the years. Within this context, it´s necessary to obtain safe and effective therapies for control and management of the patient in cases of osteoarthritis and osteoarthrosis of the TMJ. Therapeutic options range from intra-articular infiltration protocols, occlusal splints, pharmacological therapies and physiotherapy and educational measures. The alternative treatment with structure-modifying agents, like as chondroitin and glucosamine sulfates, showed promising results, and especially safety. Thus, through a systematic literature review, this study aimed to analyze and discuss effectiveness and safety of chondroitin and glucosamine in degenerative changes of the TMJ. Methods: Survey in research bases: MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and January 2009, with focus in randomized clinical trial (RCTs) and quasi-randomized clinical trials, systematic reviews and meta-analysis. Results: After application of the inclusion criteria was reached 2 articles, both randomized controlled double-blind clinical trials, which evaluated the effectiveness of chondroitin and glucosamine in degenerative changes of the TMJ. Conclusions: There is necessary further RCT, with representative samples and long follow-up time, to obtainment cause-effect relationships more precise and to achieve an objective and effective protocol involving chondroitin and glucosamine in cases of degenerative changes of the TMJ.

Keywords: Chondroitin. Glucosamine. Temporomandibular joint. Temporomandibular disorder. Osteoarthrosis. Osteoarthritis.

How to cite: Machado E, Machado P, Cunali PA. Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: A systematic review. Dental Press J Orthod. 2012 July-Aug;17(4):19-20.

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