Botulinum toxin for treating muscular temporomandibular disorders: A systematic review

Eduardo MACHADO, Lívia Zuchetto dos SANTOS, Lilian Gonçalves CUSTÓDIO, Paulo Afonso CUNALI

Objective: This study, through a systematic literature review, aims to analyze the effectiveness of Botulinum Toxin as a treatment for masticatory myofascial pain and muscles temporomandibular disorders (TMD). Methods: Survey in research bases: MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and April 2011, with focus in randomized or quasi-randomized controlled clinical trials, blind or double-blind. Results: After applying the inclusion criteria, 4 articles comprised the final sample: 3 were double-blind randomized controlled clinical trials and 1 was single-blind randomized controlled clinical trial. Conclusions: According to the literature, there is lack of evidence about the real effectiveness of botulinum toxin in the treatment of masticatory myofascial pain and muscular TMD. Thus, further randomized controlled clinical trials, with representative samples and longer follow-up time, to assess the real effectiveness of the technique are needed.

Keywords: Botulinum toxins type A. Botulinum toxins. Temporomandibular joint dysfunction syndrome. Temporomandibular joint disorders. Myofascial pain syndromes.

How to cite: Machado E, Santos LZ, Custódio LG, Cunali PA. Botulinum toxin for treating muscular temporomandibular disorders: A systematic review. Dental Press J Orthod. 2012 Nov-Dec;17(6):167-71.

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